Synthesis of 8-(5-Aryl-4-Octyl-2-Phenyl-3, 4-Dihydro-2H-Pyrazol- 3-yl)-Octanoic acid ethyl esters via 1, 3-Dipolar Cycloaddition Reaction
نویسندگان
چکیده
Aldehyde phenyl hydrazones 2a-i undergo oxidative dehydrogenation with Chloramine-T to give nitrile imines, which are trapped in situ by ethyl oleate 1 to afford 8-(5-Aryl-4-octyl-2-phenyl-3,4-dihydro-2Hpyrazol-3-yl)-octanoic acid ethyl esters 3a-i in good yield. The structures of the cycloadducts were confirmed by spectral studies and elemental analysis.
منابع مشابه
Evaluation of New Tetra Substituted Pyrazolines for Their Antimicrobial and Antioxidant Activity; Structure-Activity Relationship
A series of synthesized new 8-[5-aryl-4-octyl-2-phenyl-3,4-dihydro-2H-pyrazol-3-yl]-octanoic acid ethyl esters 1 were evaluated in vitro for their antibacterial and antifungal activity against different organisms. The compounds were tested for their antioxidant activity and their reducing power ability. The structure-activity relationship of the compounds was described.
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